Free books on Pharmacology,Drug interactions,Medicine,Bioinformatics

Foundations of Comparative Genomics
Pages: 280

This book provides an overview of computational analysis of genes and genomes,
and of some most notable findings that come out of this work. Foundations of
Comparative Genomics presents a historical perspective, beginning with early
analysis of individual gene sequences, to present day comparison of gene
repertoires encoded by completely sequenced genomes. The author discusses the
underlying scientific principles of comparative genomics, argues that
completion of many genome sequences started a new era in biology, and provides
a personal view on several state-of-the-art issues, such as systems biology and
whole-genome phylogenetic reconstructions. This book is an essential reference
for researchers and students in computational biology, evolutionary biology,
and genetics.

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New and Emerging Proteomic Techniques
Pages: 248

Leading researchers and innovators describe in step-by-step detail the latest
techniques that promise to significantly impact the practice of proteomics, as
well as its success in developing novel clinical agents. The methods span the
entire spectrum of top-down and bottom-up approaches, including microarrays,
gels, chromatography, and affinity separations, and address every aspect of the
human proteome, both quantitatively and qualitatively. The techniques of
protein detection utilized are diverse and range from fluorescence and
resonance light scattering to surface plasmon resonance and mass spectrometry.
The protocols follow the successful Methods in Molecular Biology™ series
format, each offering step-by-step laboratory instructions, an introduction
outlining the principles behind the technique, lists of the necessary equipment
and reagents, and tips on troubleshooting and avoiding known pitfalls.

http://rapidshare.com/files/59115060/Nede1588295192.rar

Regulatory RNAs
Pages: 550

http://rapidshare.com/files/59114828/Stillm0879698187.rar

Molecular Neurology

Why a book on molecular neurology? Molecular neuroscience is advancing at a
spectacular rate. As it does so, it is revealing important clues to the
pathogenesis and pathophysiology of neurological diseases, and to the
therapeutic targets that they present. Medicines work by targeting molecules.
The more specific the targeting, the more specific the actions, and the fewer
the side effects. This book highlights, for graduate and MD-PhD students,
research fellows and research-oriented clinical fellows, and researchers in the
neurosciences and other biomedical sciences, the principles underlying
molecular medicine as related to neurology. Written by internationally
recognized experts, this well-illustrated and well-referenced book presents the
most up-to-date principles and disease examples relevant to molecular
neurology, and reviews the concepts, strategies, and latest progress in this
field. This book will interest anyone studying the molecular basis of
neurology, or developing new therapies in neurology.

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Chemical Genomics: Reviews and Protocols
Pages: 296

An up-to-date introduction for the uninitiated into the various "flavors" of
chemical genomics with a series of readily reproducible techniques for
applications in organic chemistry, protein chemistry, and computer science,
emphasizing the high-throughput approaches that are the essence of chemical
genomics. The techniques range from the classic design of small molecules as
affinity ligands for specific protein families, to in silico docking for
computational approaches to protein-small molecule interactions, to producing
highly diverse collections of proteins, carbohydrates, and small molecules for
use in arrays containing large numbers of these molecules. There are also
methods for the production of proteins and carbohydrates using different
expression systems, for analyzing proteins using mass spectrometry, and for
arraying proteins and carbohydrates on solid supports. The protocols follow the
successful Methods in Molecular Biology™ series format, each offering
step-by-step laboratory instructions, an introduction outlining the principles
behind the technique, lists of the necessary equipment and reagents, and tips
on troubleshooting and avoiding known pitfalls.

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Microbial Genomics and Drug Discovery
Exploring innovative routes of drug discovery in the postgenomic era, Microbial
Genomics and Drug Discovery examines bioinformatic and genomic approaches for
the identification, detection, selection, and validation of new antibacterial
targets and vaccine candidates. The book discusses potential pathways for
effective infection control, inhibition of antibacterial resistance, and
acceleration of the drug discovery process. This read.freeduan.com
comprehensive reference describes procedures to recognize common targets in
various bacterial species for the design of broad-spectrum antibiotics and
clearly illustrates the use of pathway tools in a genomics-based drug discovery
project.
http://rapidshare.com/files/35204913/Dou_MiGeaDrDi.rar

Probabilistic Modelling in Bioinformatics and Medical Informatics by Dirk
Husmeier
Probabilistic Modelling in Bioinformatics and Medical Informatics has been
written for researchers and students in statistics, machine learning, and the
biological sciences. The first part of this book provides a self-contained
introduction to the methodology of Bayesian networks. The following parts
demonstrate how these methods are applied in bioinformatics and medical
informatics. All three fields - the methodology of probabilistic modeling,
bioinformatics, and medical informatics - are evolving very quickly. The text
should therefore be seen as an introduction, offering both elementary tutorials
as well as more advanced applications and case studies.
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Intelligent Bioinformatics: The Application of Artificial Intelligence
Techniques to Bioinformatics Problems
Bioinformatics is contributing to some of the most important advances in
medicine and biology. At the forefront of this exciting new subject are
techniques known as artificial intelligence which are inspired by the way in
which nature solves the problems it faces. This book provides a unique insight
into the complex problems of bioinformatics and the innovative solutions which
make up ��intelligent bioinformatics��.

http://rapidshare.com/files/40045416/Keedwell.rar.html

Knowledge Discovery in Bioinformatics: Techniques, Methods, and Applications

The purpose of this edited book is to bring together the ideas and findings of
data mining researchers and bioinformaticians by discussing cutting-edge
research topics such as, gene expressions, protein/RNA structure prediction,
phylogenetics, sequence and structural motifs, genomics and proteomics, gene
findings, drug design, RNAi and microRNA analysis, text mining in
bioinformatics, modelling of biochemical pathways, biomedical ontologies,
system biology and pathways, and biological database management.
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Bioinformatics and Drug Discovery (Methods in Molecular Biology)
A collection of readily reproducible bioinformatic methods to advance the drug
discovery process from gene identification to protein modeling to the
identification of specific drug candidates. The authors demonstrate these
techniques, read.freeduan.com including microarray analysis, the analysis of
genes as potential drug targets, virtual screening and in silico protein
design, and cheminformatics, in a variety of practical situations. Because
these technologies are still emergent, each chapter contains an extended
introduction that explains the theory and application of the technology and
techniques described.

http://rapidshare.com/files/31280893/Lar_BiaDD_M316giga.rar

Molecular Interaction Fields: Applications in Drug Discovery and ADME
Prediction (Methods and Principles in Medicinal Chemistry)
Book Description:
This unique reference source, edited by the world's most respected expert on
molecular interaction field software, covers all relevant principles of the
GRID force field and its applications in medicinal chemistry. Entire chapters
on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and
protein selectivity studies, among others, offer a concise freeduan.com
overview of this emerging field. As an added bonus, this handbook includes a
CD-ROM with the latest commercial versions of the GRID program and related

software.

http://rapidshare.com/files/34082319/Cru_MoInFiApiDrDiaADPr.rar

Chemoinformatics: Concepts, Methods, and Tools for Drug Discovery (Methods in
Molecular Biology)
Well-recognized pioneers and investigators from diverse professional
environments survey the key concepts in the field, describe cutting-edge
methods, and provide exemplary pharmaceutical applications. The authors explain
the theory behind the crucial concepts of molecular similarity and diversity,
describe the challenging efforts to use chemoinformatics approaches to virtual
and high-throughput screening, and illuminate the latest developments in
multidimensional QSAR analysis.

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Chemoinformatics in Drug Discovery (Methods and Principles in Medicinal Chemistry)
This handbook provides the first-ever inside view of today's integrated
approach to rational drug design. Chemoinformatics experts from large
pharmaceutical companies, as well as from chemoinformatics service providers
and from academia demonstrate what can be achieved today by harnessing the
power of computational methods for the drug discovery process.
An invaluable resource for drug developers and medicinal chemists in academia
and industry.

http://rapidshare.com/files/34088734/Opr_ChiniDrDiforgiga.rar

Fragment-based Approaches in Drug Discovery (Methods and Principles in
Medicinal Chemistry)
This first systematic summary of the impact of fragment-based approaches on the
drug development process provides essential information that was previously
unavailable. Adopting a practice-oriented approach, this represents a book by
professionals for professionals, tailor-made for drug developers in the pharma
and biotech sector who need to keep up-to-date on the latest technologies and
strategies in pharmaceutical ligand design. The book is clearly divided into
three sections on ligand design, spectroscopic techniques, and screening and
drug discovery, backed by numerous case studies.

http://rapidshare.com/files/34640157/Jah_FbAiDD.rar

Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective (Methods and Principles in Medicinal Chemistry)
Chemogenomics brings together the most powerful concepts in modern chemistry
and biology, linking combinatorial chemistry with genomics and proteomics.The
first reference devoted to the topic, this up-to-date resource covers all
stages of the early drug discovery process, from target selection to compound
library and lead design.With the combined expertise of 20 research groups from
academia and from leading pharmaceutical companies, this book is freeduancom a
must-have for every drug developer and medicinal chemist applying the powerful
methods of chemogenomics to speed up the drug discovery process.

http://rapidshare.com/files/34085721/Kub_ChgeiDrDiAMeChPe.rar


High-Throughput Screening in Drug Discovery (Methods and Principles in
Medicinal Chemistry)
Backed by leading authorities, this is a professional guide to successful
compound screening in pharmaceutical research and chemical biology, including
the chemoinformatic tools needed for correct data evaluation. Chapter authors
from leading pharmaceutical companies as well as from Harvard University
discuss such factors as chemical genetics, binding, cell-based and biochemical
assays, the efficient use of compound libraries and data mining using
cell-based assay results.
For both academics and professionals in the pharma and biotech industries
working on small molecule screening.

http://rapidshare.com/files/34639651/Hus_HTpSiDD.rar

Enzyme Assays: High-throughput Screening
http://rapidshare.com/files/46801731/Enzyme_Assays.pdf
http://mihd.net/1idpw8

Optimization in Drug Discovery (Methods in Pharmacology and Toxicology)
A panel of researchers and experts from leading universities and major
pharmaceutical companies from all over the world systematically describe
cutting-edge experimental protocols for the early in vitro evaluation of new
chemical entities (NCE). These readily reproducible assays measure such
critical parameters as physicochemical properties, adsorption, plasma
freeduan.com binding, metabolism, drug interactions, and toxicity. By
uncovering early in the discovery stage the defects that can eliminate
candidate drugs from preclinical and clinical development, these techniques can
save millions of dollars in time and effort.

http://rapidshare.com/files/36159043/yany_oiddivmmpt.rar

http://rapidshare.com/files/36178275/Optimization_in_Drug_Discovery_1588293327.rar

Drug Stereochemistry: Analytical Methods and Pharmacology (Clinical
Pharmacology, No 18)

Maintaining and enhancing its focus on key issues in the development,
regulatory approval and use of stereoisomeric compounds, this edition continues
to cover in detail all aspects of chiral drugs from the academic, governmental,
industrial read.freeduan.com and clinical points of view.;Completely rewritten
and updated throughout, Drug Stereochemistry: illustrates current indirect
chromatographic methods for the resolution of drug enantiomers; treats the
rapidly growing area of enantioselective gas chromatography; discusses the
latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to
show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies
an in-depth study on the effect of stereoselective plasma protein binding.;This
edition offers entirely new chapters that: discuss the recent decisions and
present position of the US Food and Drug Administration on the development of
stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure
drugs; review the toxicological, pharmacokinetic and pharmacodynamic
differences found among stereoisomers; elucidate the stereoselective transport
of drugs across epithelia; and give a physician's perspective on the questions
and problems caused by stereoisomeric drugs in practice as well as the
pharmaceutical industry's collective viewpoint based on a national survey.
57.82M

http://rapidshare.com/files/41208334/Wain_DSCAMaP2e.rar

Introductory Clinical Pharmacology (7th Ed) and Lww 2007 Drug Guide
This text presents a clear, concise introduction to pharmacology. Designed for
the LPN/LVN student, the book focuses on basic principles and the nurse's
responsibility in drug administration. Organized by body system, the book
examines pharmacologic properties and therapeutic applications of drugs as a
class or group. Summary Drug Tables present generic and trade drug names, uses,
adverse reactions, and usual dosage ranges. Features include updated drug
tables, gerontologic alerts, special considerations, home care checklists, and
patient and family teaching boxes. New to this edition: complementary therapies
information, dimensional analysis review, chapter summary questions, drug
category flowcharts, math review problems, and full color throughout.

http://rapidshare.com/files/6360760/Roach_Introductory_Clinical_Pharmacology_7th_Ed.rar
http://mihd.net/te5v1a

Modern Pharmacology with Clinical Applications 6th Ed.
The Sixth Edition of this updated and comprehensive textbook is designed to be
used during a single semester, the book focuses on the clinical application of
drugs within a context of the major principles of pharmacology. It is designed
to serve students in medicine, osteopathy, dentistry, pharmacy and advanced
nursing, as well as undergraduate students.
http://rapidshare.com/files/31008244/Modern_Pharmacology_With_Clinical_Applications_6th.Ed.rar

Diuretic Agents: Clinical Physiology and Pharmacology
The only comprehensive work to cover all aspects of diuretic agents, the book
discusses the pharmacology and toxicology of diuretic agents as well as the
physiological effects. Experts in the field present the principles and
experimental approaches for the study of interactions between pharmacologic
compounds in relation to specific target organs. Diuretic Agents contains
information on the mechanisms of action and application of diuretics, and
details FDA regulations and pharmaceutical industry guidelines.
http://mihd.net/46zuol
http://rapidshare.com/files/63954158/diuretic.rar

Reviews of Physiology, Biochemistry and Pharmacology
http://rapidshare.com/files/29456249/Ama_RoPBaPV153forgiga.rar

Reviews of Physiology, Biochemistry, and Pharmacology / Volume 152: Special
Issue on Emerging Bacterial Toxins (Reviews of Physiology, Biochemistry, and
Pharmacology)

http://rapidshare.com/files/29456203/Akt_RoPBaPV152forgiga.rar

The p53 Tumor Suppressor Pathway and Cancer (Protein Reviews Volume 2)
The p53 tumor suppressor gene is mutated in approximately half of all human
malignancies, including colon, lung, and breast cancers. It is well recognized
that these mutations directly inactivate p53 tumor suppressor function.
Furthermore, the p53 protein operates within a pathway and this pathway,
including the mutations in p53, is likely inactivated by nearly every human
tumor. In support of this hypothesis, 100% of mice that have been engineered
such that they do not express p53 protein (knockout animals), develop highly
malignant tumors by only 3-6 months of age. The importance of p53 in preventing
human cancer is also evident by families in which a mutated p53 gene is
inherited from a parent.
http://rapidshare.com/files/41766649/Zamb_Tp5TSPwaCPR2.rar

Lippincott's Illustrated Reviews : Pharmacology
Students and faculty alike have attested to the extraordinary success rate of
the Lippincott's Illustrated Reviews--the unparalleled review texts that
clarify the essentials students need to know for the Boards through an
easy-to-use outline format and illustration program. Now, the Pharmacology
review has been updated and enhanced to ensure that students fully master the
most current information.
http://files.to/get/48256/56563/Lippincott__s_Illustrated_Reviews_-_Pharmacology_-_2nd_Edition.rar

Lippincott - Textbook of Neurology 10e.pdf
Merritt's Neurology 10th Edition (June 2000): by H. Houston Textbook of
Neurology Merritt (Editor), Lewis P. Rowland (Editor), Randy Rowland By
Lippincott
Williams & Wilkins Publishers
http://www.megaupload.com/?d=GVUO42PG

Lippincott Manual of Nursing Practice
Completely updated for its Eighth Edition, this full-color classic reference is
the one source every nurse needs for essential patient assessment and treatment
guidelines. In an easy-to-read outline format, this clinically focused guide
covers all disorders and patient problems in Medical-Surgical,
Maternal-Neonatal, Pediatric, and Psychiatric nursing, and includes over 150
step-by-step procedures.Each Eighth Edition chapter incorporates and identifies
official guidelines that shape clinical practice
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Manual of Skin Diseases
Concisely written, the Manual of Skin Diseases provides a succinct overview of
all areas of dermatology. This handy guide provides step-by-step instruction on
the identification and management of skin diseases from diagnosis and
description to detailed information on follow-up therapy. Topics covered in
this liberally illustrated reference include cosmetics, geographic skin
disease, and pediatric and geriatric skin diseases.
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Diseases And Disorders: A Nursing Therapeutics Manual
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From lippincott : Basic Cardiac Auscultation CD
all heart sounds ( normal and abnormal ) for medical students and health
professionals
Size: 33MB
http://rapidshare.de/files/24292460/HeartSounds_lipincoat.part1.rar
http://rapidshare.de/files/24280524/HeartSounds_lipincoat.part2.rar
http://rapidshare.de/files/24236603/HeartSounds_lipincoat.part3.rar